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Acta Veterinaria Scandinavica

, 53:61

First Online: 18 November 2011Received: 26 September 2011Accepted: 18 November 2011

Abstract

Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick Haemophysalis leporis-palustris in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from < 1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats VNTR analysis MLVA system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.

Electronic supplementary materialThe online version of this article doi:10.1186-1751-0147-53-61 contains supplementary material, which is available to authorized users.

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Autor: Cristina M Hansen - Amy J Vogler - Paul Keim - David M Wagner - Karsten Hueffer

Fuente: https://link.springer.com/



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