The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in ratReport as inadecuate




The antiinflammatory potential of phenolic compounds from Emblica officinalis L. in rat - Download this document for free, or read online. Document in PDF available to download.

Inflammopharmacology

, Volume 19, Issue 6, pp 327–334

First Online: 02 July 2010Received: 28 February 2010Accepted: 13 April 2010

Abstract

Antiinflammatory effects of phenolic compounds from Emblica officinalis were evaluated in carrageenan and cotton pellet induced acute and chronic inflammatory animal model. Fractions of E. officinalis containing free FPEO and bounded BPEO phenolic compounds were assessed by HPLC technique. The free and bound phenolic compounds were studied for their acute and chronic antiinflammatory activity at dose level of 20 and 40 mg-kg. The carrageenan induced acute inflammation was assessed by measuring rat paw volume at different time of intervals. Further, cotton pellet induced chronic inflammation was assessed by granulomatous tissue mass estimation along with the estimation of tissue biomarker changes i.e. lipid peroxidation, reduced glutathione, myeloperoxidase and plasma extravasation. The results indicated that in both acute and chronic inflammation, FPEO and BPEO show reduction in the inflammation, but significant effects was observed only at high doses of both fractions which was comparable to diclofenac treated group. In conclusion, phenolic compounds of E. officinalis may serve as potential herbal candidate for amelioration of acute and chronic inflammation due to their modulatory action of free radicals.

KeywordsEmblica officinalis Chronic inflammation Myeloperoxidase Evans blue  Download fulltext PDF



Author: Arunachalam Muthuraman - Shailja Sood - Sumeet Kumar Singla

Source: https://link.springer.com/







Related documents