Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbancesReport as inadecuate




Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances - Download this document for free, or read online. Document in PDF available to download.

Mediterranean Journal of Nutrition and Metabolism

, Volume 4, Issue 3, pp 211–218

First Online: 17 December 2010Received: 23 November 2010Accepted: 02 December 2010

Abstract

Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos, a standardized Melissa officinalis L. extract, was administrated. Cyracos contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate the efficacy of Cyracos on stressed volunteers, who have mild-to-moderate anxiety disorders and sleep disturbances. Using clinician rating criteria, primary outcomes showed improvement of symptoms. Cyracos reduced anxiety manifestations by 18% p < 0.01, ameliorated anxiety-associated symptoms by 15% p < 0.01 and lowered insomnia by 42% p < 0.01. As much as 95% of subjects 19-20 responded to treatment, of which 70% 14-20 achieved full remission for anxiety, 85% 17-20 for insomnia, and 70% 14-20 for both. Our study demonstrates, for the first time that chronic administration of Melissa officinalis L. relieves stress-related effects. It is critical that further studies incorporate a placebo and investigate physiological stress markers.

KeywordsMelissa officinalis L. Anxiety Insomnia Free Rating Scale for Anxiety FRSA Hamilton Rating Scale for Depression HRSD Gamma-aminobutyric acid GABA  Download fulltext PDF



Author: Julien Cases - Alvin Ibarra - Nicolas Feuillère - Marc Roller - Samir G. Sukkar

Source: https://link.springer.com/







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