Advances in MRI-Based Detection of Cerebrovascular Changes after Experimental Traumatic Brain InjuryReport as inadecuate

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Translational Stroke Research

, Volume 2, Issue 4, pp 524–532

First Online: 12 November 2011Received: 14 September 2011Revised: 25 October 2011Accepted: 26 October 2011


Traumatic brain injury is a heterogeneous and multifaceted neurological disorder that involves diverse pathophysiological pathways and mechanisms. Thorough characterization and monitoring of the brain’s status after neurotrauma is therefore highly complicated. Magnetic resonance imaging MRI provides a versatile tool for in vivo spatiotemporal assessment of various aspects of central nervous system injury, such as edema formation, perfusion disturbances and structural tissue damage. Moreover, recent advances in MRI methods that make use of contrast agents have opened up additional opportunities for measurement of events at the level of the cerebrovasculature, such as blood–brain barrier permeability, leukocyte infiltration, cell adhesion molecule upregulation and vascular remodeling. It is becoming increasingly clear that these cerebrovascular alterations play a significant role in the progression of post-traumatic brain injury as well as in the process of post-traumatic brain repair. Application of advanced multiparametric MRI strategies in experimental, preclinical studies may significantly aid in the elucidation of pathomechanisms, monitoring of treatment effects, and identification of predictive markers after traumatic brain injury.

KeywordsAnimal models Contrast agents Magnetic resonance imaging Neuroinflammation Traumatic brain injury  Download fulltext PDF

Author: Rick M. Dijkhuizen


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