Antibacterial potential of silver nanoparticles against isolated urinary tract infectious bacterial pathogensReport as inadecuate




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Applied Nanoscience

, Volume 1, Issue 4, pp 231–236

First Online: 21 September 2011Received: 14 July 2011Accepted: 08 September 2011

Abstract

The silver nanoparticles were synthesized by chemical reduction method and the nanoparticles were characterized using ultraviolet–visible UV–Vis absorption spectroscopy and X-ray diffraction XRD studies. The synthesized silver nanoparticles were investigated to evaluate the antibacterial activity against urinary tract infectious UTIs bacterial pathogens. Thirty-two bacteria were isolated from mid urine samples of 25 male and 25 female patients from Thondi, Ramanathapuram District, Tamil Nadu, India and identified by conventional methods. Escherichia coli was predominant 47% followed by Pseudomonas aeruginosa 22%, Klebsiella pneumoniae 19%, Enterobacter sp. 6%, Proteus morganii 3% and Staphylococcus aureus 3%. The antibacterial activity of silver nanoparticles was evaluated by disc diffusion assay. P. aeruginosa showed maximum sensitivity 11 ± 0.58 mm followed by Enterobacter sp. 8 ± 0.49 mm at a concentration of 20 μg disc and the sensitivity was highly comparable with the positive control kanamycin and tetracycline. K. pneumoniae, E. coli, P. morganii and S. aureus showed no sensitivity against all the tested concentrations of silver nanoparticles. The results provided evidence that, the silver nanoparticles might indeed be the potential sources to treat urinary tract infections caused by P. aeruginosa and Enterobacter sp.

KeywordsAntibacterial sensitivity Disc diffusion assay Silver nanoparticles UTI  Download fulltext PDF



Author: Samuel Jacob Inbaneson - Sundaram Ravikumar - Nachiappan Manikandan

Source: https://link.springer.com/







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