Local interleukin-10 production during respiratory syncytial virus bronchiolitis is associated with post-bronchiolitis wheezeReport as inadecuate




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Respiratory Research

, 12:121

First Online: 01 December 2011Received: 23 May 2011Accepted: 12 September 2011

Abstract

BackgroundRespiratory syncytial virus RSV is the most common cause of bronchiolitis in infants. Following RSV bronchiolitis, 50% of children develop post-bronchiolitis wheeze PBW. Animal studies have suggested that interleukin IL-10 plays a critical role in the pathogenesis of RSV bronchiolitis and subsequent airway hyperresponsiveness. Previously, we showed that ex vivo monocyte IL-10 production is a predictor of PBW. Additionally, heterozygosity of the single-nucleotide polymorphism SNP rs1800872 in the IL10 promoter region was associated with protection against RSV bronchiolitis.

MethodsThis study aimed to determine the in vivo role of IL-10 in RSV pathogenesis and recurrent wheeze in a new cohort of 235 infants hospitalized for RSV bronchiolitis. IL-10 levels in nasopharyngeal aspirates NPAs were measured at the time of hospitalization and the IL10 SNP rs1800872 genotype was determined. Follow-up data were available for 185 children 79%.

ResultsLocal IL-10 levels during RSV infection turned out to be higher in infants that later developed physician diagnosed PBW as compared to infants without PBW in the first year after RSV infection 958 vs 692 pg-ml, p = 0.02. The IL10 promoter SNP rs1800872 was not associated with IL-10 concentration in NPAs.

ConclusionThe relationship between high local IL-10 levels during the initial RSV infection and physician diagnosed PBW provides further evidence of the importance of the IL-10 response during RSV bronchiolitis.

Keywordsinterleukin-10 lower respiratory tract infection respiratory syncytial virus wheeze List of abbreviations usedCIconfidence interval

ILinterleukin

NPAnasopharyngeal aspirate

ORodds ratio

PBWpost-bronchiolitis wheeze

RSVrespiratory syncytial virus

SNPsingle-nucleotide polymorphism.

Electronic supplementary materialThe online version of this article doi:10.1186-1465-9921-12-121 contains supplementary material, which is available to authorized users.

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Author: Annemieke Schuurhof - Riny Janssen - Hanneke de Groot - Hennie M Hodemaekers - Arja de Klerk - Jan LL Kimpen - Louis Bont

Source: https://link.springer.com/







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