Membranoproliferative glomerulonephritis and a rare bleeding disorder: factor X deficiencyReport as inadecuate

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International Urology and Nephrology

, Volume 43, Issue 4, pp 1237–1241

First Online: 23 September 2010Received: 25 April 2010Accepted: 27 August 2010


Factor X FX deficiency is a rare hereditary coagulation disorder. This is the first case report on the association of FX deficiency and membranoproliferative glomerulonephritis MPGN type I. The patient, a 17-year-old male, presented with edema, hypertension, and microscopic hematuria, followed by a mild upper respiratory tract infection. Laboratory tests revealed: serum creatinine 1.6 mg-dl, serum albumin 2.80 g-dl, C3 16 mg-dl and proteinuria 1,800 mg-day. The renal biopsy showed MPGN type I. The coagulation profile prior to percutaneous renal biopsy revealed prolonged prothrombin time and activated partial thromboplastin time values. The patient was given fresh frozen plasma and vitamin K before the biopsy. Further evaluation showed the functional activity of FX was 7% of the norm. This case emphasizes the need for routine coagulation screening before percutaneous renal biopsy.

KeywordsMPGN Type I Factor X deficiency Percutaneous renal biopsy  Download fulltext PDF

Author: T. Basturk - E. Ahbap - B. Eroglu Kesim - M. Yılmaz - Y. Koç - T. Sakacı - A. Unsal


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