Isorosthornins A-C, new ent-kaurane diterpenoids from Isodon rosthorniiReport as inadecuate

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Natural Products and Bioprospecting

, Volume 1, Issue 3, pp 116–120

First Online: 12 December 2011Received: 17 November 2011Accepted: 07 December 2011


Three new ent-kauranoids, isorosthornins A-C 1–3 , and a new natural product, dihydroponicidin 4 , together with five known ones were isolated from the aerial parts of Isodon rosthornii. The structures were determined by means of extensive spectroscopic analysis. All diterpenoids isolated were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines, and compounds 5 and 7 showed significant inhibitory effects on all cell lines. Open image in new window

KeywordsIsodon rosthornii ent-kaurane diterpenoid cytotoxicity This article is published with open access at

Electronic Supplementary MaterialSupplementary material is available for this article at 10.1007-s13659-011-0031-7 and is accessible for authorized users.

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Author: Rui Zhan - Xue Du - Jia Su - Xiao-Nian Li - Wei-Guang Wang - Cheng-Qin Liang - Jian-Hong Yang - Yan Li - Jian-Xin Pu - Ha


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