Comparison of the temporal release pattern of copeptin with conventional biomarkers in acute myocardial infarctionReport as inadecuate

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Clinical Research in Cardiology

, Volume 100, Issue 12, pp 1069–1076

First Online: 16 July 2011Received: 01 March 2011Accepted: 01 July 2011


BackgroundEarly detection of acute myocardial infarction AMI using cardiac biomarkers of myocardial necrosis remains limited since these biomarkers do not rise within the first hours from onset of AMI. We aimed to compare the temporal release pattern of the C-terminal portion of provasopressin copeptin with conventional cardiac biomarkers, including creatine kinase isoenzyme CK-MB, cardiac troponin T cTnT, and high-sensitivity cTnT hs-cTnT, in patients with ST-elevation AMI.

MethodsWe included 145 patients undergoing successful primary percutaneous coronary intervention PCI for a first ST-elevation AMI presenting within 12 h of symptom onset. Blood samples were taken on admission and at four time points within the first 24 h after PCI.

ResultsIn contrast to all other markers, copeptin levels were already elevated on admission and were higher with a shorter time from symptom onset to reperfusion and lower systolic blood pressure. Copeptin levels peaked immediately after symptom onset at a maximum of 249 pmol-L and normalized within 10 h. In contrast, CK-MB, cTnT, and hs-cTnT peaked after 14 h from symptom onset at a maximum of 275 U-L, 5.75 μg-L, and 4.16 μg-L, respectively, and decreased more gradually.

ConclusionsCopeptin has a distinct release pattern in patients with ST-elevation AMI, peaking within the first hour after symptom onset before conventional cardiac biomarkers and falling to normal ranges within the first day. Further studies are required to determine the exact role of copeptin in AMI suspects presenting within the first hours after symptom onset.

KeywordsCopeptin Acute myocardial infarction Biomarkers Temporal release pattern Troponin  Download fulltext PDF

Author: Youlan L. Gu - Adriaan A. Voors - Felix Zijlstra - Hans L. Hillege - Joachim Struck - Serge Masson - Tarcisio Vago - Ste


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