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Abstract: A quantitative theory on the construction and the evolution of the geneticcode is proposed. Through introducing the concept of mutational deteriorationMD and developing a theoretical formalism on MD minimization we have proved:1, the redundancy distribution of codons in the genetic code obeys MDminimization principle; 2, the hydrophilic-hydrophobic distribution of aminoacids on the code table is global MD GMD minimal; 3, the standard geneticcode can be deduced from the adaptive minimization of GMD; 4, the variants ofthe standard genetic code can be explained quantitatively by use of GMDformalism and the general trend of the evolution is GMD non-increasing whichreflects the selection on the code. We have demonstrated that the redundancydistribution of codons and the hydrophobic-hydrophilic H-P distribution ofamino acids are robust in the code relative to the mutational parameter, andindicated that the GMD can be looked as a non-fitness function on the adaptivelandscape. Finally, an important aspect on the symmetry of the codeconstruction, the Yin-Yang duality is investigated. The Yin-Yang duality amongcodons affords a sound basis for understanding the H-P structure in the geneticcode.



Author: Liaofu Luo

Source: https://arxiv.org/







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