Evaluation of the Acute Oral Toxicity Class of Trinuclear ChromiumIII Glycinate Complex in RatReport as inadecuate




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Biological Trace Element Research

, Volume 143, Issue 3, pp 1564–1575

First Online: 18 January 2011Received: 13 December 2010Accepted: 05 January 2011

Abstract

ChromiumIII is considered as an essential element playing a role in carbohydrate and lipid metabolism, and various chemical forms of this element are widely used in dietary supplements. A new trinuclear chromiumIII glycinate complex Cr3ONH2CH2CO26H2O3NO3 CrGly, an analogue of Cr3 trinuclear CrIII propionate complex has been synthesized as a potential source of supplementary Cr. In this study, we evaluated the acute toxicity class of CrGly in Wistar rats applying the OECD 423 procedure. Male and female Wistar rats n = 12, 6 ♀ and 6 ♂ were given by gavage either a single dose of CrGly 2,000 mg-kg body mass equals to 300 mg CrIII-kg body mass; in aqueous solution or equivalent volumes of distilled water and fed ad libitum commercial Labofeed B diet, and observed carefully for 14 days, then sacrificed to collect blood and internal organs for biochemical and histologic examination. No death cases were detected. No abnormalities in animal behavior, body mass gains, gross organ histology, or blood morphology and biochemistry were observed. The results demonstrate that LD50 of CrGly is greater than 2,000 mg-kg when administrated orally to rat; thus, this compound appears to belong to the fifth category in the GHS system or the fourth class -unclassified- in the EU classification system.

KeywordsChromiumIII glycinate complex Acute oral toxicity Rat  Download fulltext PDF



Author: Halina Staniek - Zbigniew Krejpcio - Katarzyna Iwanik - Henryk Szymusiak - Daria Wieczorek

Source: https://link.springer.com/







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