Treatment of Allergic Rhinitis With Desloratadine: Results of a Multinational Observational Study in the Middle East Gulf RegionReport as inadecuate




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World Allergy Organization Journal

, Volume 4, Issue 8, pp 130–134

First Online: 15 August 2011

Abstract

BackgroundAllergic rhinitis AR affects up to 36% of the population in the Middle East Gulf States. The second-generation nonsedating antihistamine desloratadine has demonstrated safety and efficacy in the treatment of AR; however, few studies have evaluated this agent in Arab and Asian populations in the Middle East.

MethodsThis open-label study enrolled subjects ≥ 12 years with moderate-to-severe AR; they received desloratadine 5 mg QD for 2 weeks. Endpoints included change in mean individual nasal and ocular symptom scores, total symptom score TSS, and peak nasal inspiratory flow PNIF and percentage improvement in global response to therapy.

ResultsThere were 602 subjects from 5 Middle East countries enrolled. After 2 weeks, desloratadine significantly P < 0.0001 reduced mean scores for individual nasal and total ocular symptom scores and TSS. PNIF measures of nasal congestion were significantly P < 0.0001 improved after treatment. Most subjects obtained complete 38.1% or marked 47.2% relief of AR symptoms. Treatment failure was reported in 2.2% of subjects. No adverse events were reported, and no subjects discontinued treatment.

ConclusionMost subjects reported significant symptom relief with desloratadine 5 mg-d for 2 weeks. Desloratadine is effective in the treatment of AR in Arab and Asian subjects in the Middle East Gulf region.

Keywordsallergic rhinitis desloratadine Middle East nasal congestion peak nasal inspiratory flow  Download fulltext PDF



Author: Tamer M. H. Adham

Source: https://link.springer.com/







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