High chromosomal instability in adenocarcinoma of the ileum arising from multifocal gastric heterotopia with gastritis cystica profundaReport as inadecuate




High chromosomal instability in adenocarcinoma of the ileum arising from multifocal gastric heterotopia with gastritis cystica profunda - Download this document for free, or read online. Document in PDF available to download.

Medical Oncology

, Volume 28, Issue 4, pp 1023–1026

First Online: 25 June 2010Received: 28 May 2010Accepted: 14 June 2010

Abstract

Adenocarcinoma of the small intestine arising from heterotopic gastric mucosa is extremely rare. In this report, we present the case of a 68-year-old woman who complained of abdominal pain, weight loss and subileus. Gross examination of resected small bowel revealed multiple flat polypous lesions with cysts in the ileal submucosa, one of which containing an ulcerated, stenosing tumour. On microscopic examination, an adenocarcinoma of the ileum arising from multifocal gastric heterotopia with secondary gastritis cystica profunda was diagnosed. Comparative genomic hybridization of the adenocarcinoma revealed chromosomal gains at 1q, 3q, 5p, 8q, 11p, 12p, 13q and losses at Xp, 4q, 8p, 10p, 14q, 17p, 20p, compatible with a high degree of genomic instability.

KeywordsGastric heterotopia Gastritis cystica profunda Adenocarcinoma Ileum Comparative genomic hybridization Informed consent Written informed consent was obtained from the patient. A copy of the written consent is available for review by the Editor-in-Chief of this journal.

Download fulltext PDF



Author:

Source: https://link.springer.com/







Related documents