Radiation techniques for acromegalyReport as inadecuate

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Radiation Oncology

, 6:167

First Online: 02 December 2011Received: 07 September 2011Accepted: 02 December 2011


Radiotherapy RT remains an effective treatment in patients with acromegaly refractory to medical and-or surgical interventions, with durable tumor control and biochemical remission; however, there are still concerns about delayed biochemical effect and potential late toxicity of radiation treatment, especially high rates of hypopituitarism. Stereotactic radiotherapy has been developed as a more accurate technique of irradiation with more precise tumour localization and consequently a reduction in the volume of normal tissue, particularly the brain, irradiated to high radiation doses. Radiation can be delivered in a single fraction by stereotactic radiosurgery SRS or as fractionated stereotactic radiotherapy FSRT in which smaller doses are delivered over 5-6 weeks in 25-30 treatments. A review of the recent literature suggests that pituitary irradiation is an effective treatment for acromegaly. Stereotactic techniques for GH-secreting pituitary tumors are discussed with the aim to define the efficacy and potential adverse effects of each of these techniques.

Keywordsacromegaly fractionated stereotactic radiotherapy radiosurgery toxicity GH-secreting pituitary tumors  Download fulltext PDF

Author: Giuseppe Minniti - Claudia Scaringi - Riccardo Maurizi Enrici

Source: https://link.springer.com/

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