Simulation of haemodynamic flow in head and neck cancer chemotherapyReport as inadecuate

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BioMedical Engineering OnLine

, 10:104

First Online: 02 December 2011Received: 24 October 2011Accepted: 02 December 2011


BackgroundIn recent years, intra arterial chemotherapy has become an important component in head and neck cancer treatment. However, therapy success can vary significantly and consistent treatment guidelines are missing. The purpose of this study was to create a computer simulation of the chemical agent injection in the head and neck arteries to investigate the distribution and concentration of the chemical.

MethodsRealistic three dimensional patient specific geometry was created from image scan data. Pulsatile blood flow, turbulence, the chemical agent injection via a catheter, and the mixture between blood and the chemical were then simulated through the arterial network by computational fluid dynamics software.

ResultsThe results show a consistent chemical distribution throughout all the arteries and this is ineffective. In addition, due to high wall shear stress and turbulence at the inner bifurcation wall, serious complications during the treatment could occur, for instance haemolysis or thrombosis.

ConclusionsThe modelled catheter position is insufficient to provide a high chemical agent concentration in the desired tumour feeding artery, which is vital for therapy success.

Keywordspatient specific model blood flow dynamics non-Newtonian chemotherapy multiphase model List of abbreviations usedAPAascending pharyngeal artery

BCAbrachiocephalic artery

CADcomputer aided design

CCAcommon carotid artery

CFDcomputational fluid dynamics

CTcomputer tomography

ECAexternal carotid artery

FAfacial artery

ICAinternal carotid artery

LAlingual artery

PISOpressure implicit with splitting of operators

RSAright subclavian artery

SSTshear stress transport

STAsuperior thyroid artery

VAvertebral artery

Electronic supplementary materialThe online version of this article doi:10.1186-1475-925X-10-104 contains supplementary material, which is available to authorized users.

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Author: Stephan Rhode - Manosh C Paul - Eckhard Martens - Duncan F Campbell


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