Antidiabetic activity of isoquercetin in diabetic KK -Ay miceReport as inadecuate

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Nutrition and Metabolism

, 8:85

First Online: 02 December 2011Received: 08 October 2011Accepted: 02 December 2011


BackgroundTartary buckwheat bran is an important natural source of quercetin and isoquercetin. Quercetin and isoquercetin are both powerful α-glucosidase inhibitors. Although the IC50 of isoquercetin as α-glucosidase inhibitor was much higher than that of quercetin, the bioavailability of isoquercetin was higher than that of quercetin. Hence, we are interested in the antidiabetic effect of isoquercetin in diabetic KK -A mice.

MethodsThe hypoglycemic effect of isoquercetin in a type 2 diabetic animal model KK-A mice was studied. Isoquercetin was administrated at doses of 50, 100 and 200 mg-kg for 35 days.

ResultsIt was found that fasting blood glucose concentration was decreased with the 200 mg-kg group p < 0.01 the most efficient compared with the diabetic control group. In addition, there was significant decrease in plasma C-peptide, triglyceride, total cholesterol and blood urea nitrogen levels after 35 days. Meanwhile, glucose tolerance was improved, and the immunoreactive of pancreatic islets β-cells was promoted.

ConclusionsThese results suggest that isoquercetin had a regulative role in blood glucose level and lipids, and improved the function of pancreatic islets. Isoquercetin may be useful in the treatment of type 2 diabetes mellitus.

Keywordsisoquercetin blood glucose antidiabetic activity KK -A mice Electronic supplementary materialThe online version of this article doi:10.1186-1743-7075-8-85 contains supplementary material, which is available to authorized users.

Rui Zhang, Yang Yao contributed equally to this work.

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Author: Rui Zhang - Yang Yao - Yingping Wang - Guixing Ren


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