Microvessel density and heparanase over-expression in clear cell renal cell cancer: correlations and prognostic significancesReport as inadecuate




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World Journal of Surgical Oncology

, 9:158

First Online: 02 December 2011Received: 20 August 2011Accepted: 02 December 2011

Abstract

BackgroundTumor angiogenesis is important in the progression of malignancies, and heparanase plays an important role in sustaining the pathology of clear cell renal cell cancer ccRCC. The study was carried out to investigate the correlations between microvessel density MVD and heparanase expression containing prognostic significances in the patients with ccRCC.

MethodsSpecimens from 128 patients with ccRCC were investigated by immunohistochemistry for MVD. RT-PCR and immunohistochemistry were used to detect heparanase expression. Correlations between MVD, heparanase expression, and various clinico-pathological factors were studied. The prognostic significances of MVD and heparanase expression were also analysed.

ResultsWe discovered a statistically significant prevalence of higher MVD in ccRCC compared with adjacent normal renal tissues. MVD was positively correlated with TNM stage and distant metastasis in ccRCC patients, and was also correlated with the expression level of heparanase.

Heparanase is over-expressed and correlated with TNM stage, histologic grade, distant metastasis and lymphatic metastasis in ccRCC. High MVD and heparanase over-expression inversely correlate with the survival of ccRCC patients.

ConclusionsHeparanase contributes to angiogenesis of ccRCC and over-expression of heparanase is an independent predictors of prognosis for ccRCC. MVD is correlated with tumor development and metastasis in ccRCC.

Keywordsclear cell renal cell carcinoma microvessel density heparanase prognosis Abbreviations ListMVDmicrovessel density

HPAheparanase

RCCrenal cell carcinoma

ccRCCclear cell renal cell carcinoma

ECMextracellular matrix

BMbasement membrane

HSheparan sulfate

HSPGsheparan sulfate proteoglycans

BSAbovine serum albumin

OSOverall survival.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7819-9-158 contains supplementary material, which is available to authorized users.

Juchao Ren, Hainan Liu contributed equally to this work.

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Author: Juchao Ren - Hainan Liu - Lei Yan - Sujian Tian - Dawei Li - Zhonghua Xu

Source: https://link.springer.com/







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