Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapyReportar como inadecuado




Prolonged control of replication-competent dual- tropic human immunodeficiency virus-1 following cessation of highly active antiretroviral therapy - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Retrovirology

, 8:97

First Online: 05 December 2011Received: 12 September 2011Accepted: 05 December 2011

Abstract

BackgroundWhile initiation of highly active antiretroviral therapy HAART during primary HIV-1 infection occasionally results in transient control of viral replication after treatment interruption, the vast majority of patients eventually experience a rebound in plasma viremia.

ResultsHere we report a case of a patient who was started on HAART during symptomatic primary infection and who has subsequently maintained viral loads of < 50 copies-mL for more than nine years after the cessation of treatment. This patient had a high baseline viral load and has maintained a relatively high frequency of latently infected CD4 T cells. In addition, he does not have any known protective HLA alleles. Thus it is unlikely that he was destined to become a natural elite controller or suppressor. The mechanism of control of viral replication is unclear; he is infected with a CCR5-CXCR4 dual-tropic virus that is fully replication-competent in vitro. In addition, his spouse, who transmitted the virus to him, developed AIDS. The patient-s CD4 T cells are fully susceptible to HIV-1 infection, and he has low titers of neutralizing antibodies to heterologous and autologous HIV-1 isolates. Furthermore, his CD8 T cells do not have potent HIV suppressive activity.

ConclusionThis report suggests that some patients may be capable of controlling pathogenic HIV-1 isolates for extended periods of time after the cessation of HAART through a mechanism that is distinct from the potent cytotoxic T lymphocyte CTL mediated suppression that has been reported in many elite suppressors.

KeywordsHIV-1 elite suppressor elite controller viral replication Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-8-97 contains supplementary material, which is available to authorized users.

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Autor: Maria Salgado - S Alireza Rabi - Karen A O-Connell - Robert W Buckheit III - Justin R Bailey - Amina A Chaudhry - Autum

Fuente: https://link.springer.com/



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