Influence of the Chungkookjang on histamine-induced wheal and flare skin response: a randomized, double-blind, placebo controlled trialReport as inadecuate

Influence of the Chungkookjang on histamine-induced wheal and flare skin response: a randomized, double-blind, placebo controlled trial - Download this document for free, or read online. Document in PDF available to download.

BMC Complementary and Alternative Medicine

, 11:125

First Online: 05 December 2011Received: 23 August 2011Accepted: 05 December 2011


BackgroundAllergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, urticaria, allergic rhinitis, asthma and allergic dermatitis. The development of food products for the prevention of allergic disease is an important subject in human health. The chungkookjang CKJ has been reported to exhibit antiallergic inflammatory activity. Therefore, the aim of the study is to examine the effects of the CKJ to reduce histamine-induced wheal and flare skin responses.

Methods-DesignA randomized, double-blind, placebo-controlled study in 60 healthy subjects will be carried out. Sixty volunteers aged 20-80 who gave a written consent before entering the study will be randomized in two groups of thirty subjects each. The skin prick test with histamine solution of 10 mg-ml will be performed on the ventral forearm, 10 cm from the elbow. The subjects will be instructed to take 35 g per day of either the CKJ pills or a placebo pills for a period of 3 months. Diameters of wheal and flare will be assessing 15 minutes after performing the above-mentioned skin prick test. The primary outcome is change in wheal and flare responses. Secondary outcomes will be include change in serum histamine, immunoglobulin E, cytokines interferon-gamma, interleukin-4 -10, and tumor necrosis factor-alpha, and eosinophil cationic protein.

DiscussionThis study will show the potential anti-inflammatory properties of the CKJ in their skin activity when histamine is the challenging agent as occurs in the clinical situation. And the present protocol will confirm the efficacy and safety of the CKJ for allergy symptoms, suggesting more basic knowledge to conduct further randomized controlled trials RCT. If this study will be successfully performed, the CKJ will be an alternative dietary supplemental remedy for allergy patients.

Trial RegistrationNCT01402141

Dae-Young Kwon, Ki-Chan Ha contributed equally to this work.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-11-125 contains supplementary material, which is available to authorized users.

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Author: Dae-Young Kwon - Hye-Jeong Yang - Min-Jeong Kim - Hee-Joo Kang - Hyun-Jin Kim - Ki-Chan Ha - Hyang-Im Back - Sun-Young Kim


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