Variations in maternal care alter corticosterone and 17beta-estradiol levels, estrous cycle and folliculogenesis and stimulate the expression of estrogen receptors alpha and beta in the ovaries of UCh ratsReportar como inadecuado




Variations in maternal care alter corticosterone and 17beta-estradiol levels, estrous cycle and folliculogenesis and stimulate the expression of estrogen receptors alpha and beta in the ovaries of UCh rats - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Reproductive Biology and Endocrinology

, 9:160

First Online: 22 December 2011Received: 19 August 2011Accepted: 22 December 2011

Abstract

BackgroundVariations in maternal care are associated with neonatal stress, hormonal disturbances and reproductive injuries during adulthood. However, the effects of these variations on sex hormones and steroid receptors during ovary development remain undetermined. This study aimed to investigate whether variations in maternal care are able to influence the hormonal profile, follicular dynamics and expression of AR, ER-alpha and ER-beta in the ovaries of UCh rat offspring.

MethodsTwenty-four adult UCh rats, aged 120 days, were randomly divided into two groups UChA and UChB and mated. Maternal care was assessed from birth day 0 to the 10th postnatal day PND. In adulthood, twenty adult female rats UChA and UChB offspring; n = 10-group, aged 120 days, were euthanized by decapitation during the morning estrus.

ResultsUChA females providing high maternal care more frequently displayed the behaviors of carrying pups, as well as licking-grooming and arched back nursing cares. Also, mothers providing high care had elevated corticosterone levels. Additionally, offspring receiving low maternal care showed the highest estrous cycle duration, increased corticosterone and 17beta-estradiol levels, overexpression of receptors ER-alpha and ER-beta, increased numbers of primordial, antral and mature follicles and accentuated granulosa cell proliferation.

ConclusionsOur study suggests that low maternal care alters corticosterone and 17beta-estradiol levels, disrupting the estrous cycle and folliculogenesis and differentially regulating the expression of ER-alpha and ER-beta in the ovaries of adult rats.

Keywordsmaternal care sex steroid receptors corticosterone E2 ovary Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-9-160 contains supplementary material, which is available to authorized users.

Download fulltext PDF



Autor:

Fuente: https://link.springer.com/







Documentos relacionados