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Veterinary Research

, 42:122

First Online: 23 December 2011Received: 03 October 2011Accepted: 23 December 2011


In the last decade many studies have been performed on the virulence of Newcastle disease virus NDV. This is mainly due to the development of reverse genetics systems which made it possible to genetically modify NDV and to investigate the contribution of individual genes and genome regions to its virulence. However, the available information is scattered and a comprehensive overview of the factors and conditions determining NDV virulence is lacking. This review summarises, compares and discusses the available literature and shows that virulence of NDV is a complex trait determined by multiple genetic factors.

Electronic supplementary materialThe online version of this article doi:10.1186-1297-9716-42-122 contains supplementary material, which is available to authorized users.

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Autor: Jos CFM Dortmans - Guus Koch - Peter JM Rottier - Ben PH Peeters


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