Circulating LH-hCG receptor LHCGR may identify pre-treatment IVF patients at risk of OHSS and poor implantationReportar como inadecuado

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Reproductive Biology and Endocrinology

, 9:161

First Online: 23 December 2011Received: 01 November 2011Accepted: 23 December 2011


BackgroundSuccessful pregnancy via in vitro fertilization IVF depends on the recovery of an adequate number of healthy oocytes and on blastocyst implantation following uterine transfer. Two hormones, LH and hCG, utilize a common LH-hCG receptor LHCGR, variations in which have profound implications in human reproduction. Soluble LHCGR sLHCGR is released from experimental cell lines and placental explants and it can be detected in the follicular fluid and serum.

MethodsTo evaluate the impact of circulating soluble LHCGR sLHCGR in fertility treatment, we measured sLHCGR and LH-sLHCGR complex in serum from women seeking IVF using specifically developed quantitative enzyme-linked immunosorbent assays ELISA. Following an IVF cycle of treatment, patients were grouped according to oocyte yield into low lower than or equal to 7 oocytes, intermediate 8-14 oocytes and high greater than or equal to 15 oocytes responders and pregnancy outcome noted.

ResultsPre-treatment sLHCGR identified many women at risk of ovarian hyperstimulation. Low levels of sLHCGR were associated with pregnancy in both high and low responders but sLHCGR did not significantly affect the treatment outcome of intermediate responders. Low responders who failed to become pregnant had high levels of circulating sLHCGR bound to LH LH-sLHCGR.

ConclusionsPre-treatment measurement of sLHCGR could be used to tailor individual fertility treatment programs and improve outcomes by avoiding ovarian hyperstimulation and poor embryo implantation.

Keywordssoluble LHCGR LH-LHCGR AMH FSH OHSS IVF Pregnancy Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-9-161 contains supplementary material, which is available to authorized users.

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Autor: Anne E Chambers - Krishnaveni P Nayini - Walter E Mills - Gillian M Lockwood - Subhasis Banerjee


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