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BMC Systems Biology

, 5:S11

First Online: 23 December 2011

Abstract

BackgroundCurrently, several systems have been proposed to classify viruses and indicate the relationships between different ones, though each system has its limitations because of the complexity of viral origins and their rapid evolution rate. We hereby propose a new method to explore the relationships between different viruses.

MethodA new method, which is based on the virus-host protein-protein interaction network, is proposed in this paper to categorize viruses. The distances between 114 human viruses, including 48 HIV-1 and HIV-2 viruses, are estimated according to the protein-protein interaction network between these viruses and humans.

Conclusions-significanceThe results demonstrated that our method can disclose not only relationships consistent with the taxonomic results of currently used systems of classification but also the potential relationships that the current virus classification systems have not revealed. Moreover, the method points to a new direction where the functional relationships between viruses and hosts can be used to explore the virus relationships on a systematic level.

Electronic supplementary materialThe online version of this article doi:10.1186-1752-0509-5-S3-S11 contains supplementary material, which is available to authorized users.

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Autor: Feng Xu - Chen Zhao - Yuhua Li - Jiang Li - Youping Deng - Tieliu Shi

Fuente: https://link.springer.com/







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