No evidence for XMRV association in pediatric idiopathic diseases in FranceReportar como inadecuado




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Retrovirology

, 7:63

First Online: 02 August 2010Received: 21 May 2010Accepted: 02 August 2010

Abstract

Retroviruses have been linked to a variety of diseases such as neoplastic and immunodeficiency disorders and neurologic and respiratory diseases. Recently, a novel infectious human retrovirus, the xenotropic murine leukemia virus-related virus XMRV, has been identified in cohorts of patients with either a familial type of prostate cancer or chronic fatigue syndrome. The apparent unrelatedness of these diseases raised the question of the potential involvement of XMRV in other diseases.

Here, we investigated the presence of XMRV in a selection of pediatric idiopathic infectious diseases with symptoms that are suggestive of a retroviral infection, as well as in children with respiratory diseases and in adult patients with spondyloarthritis SpA. Using a XMRV env-nested PCR, we screened 72 DNA samples obtained from 62 children hospitalized in the Montpellier university hospital France for hematological, neurological or inflammatory pathologies, 80 DNA samples from nasopharyngeal aspirates from children with respiratory diseases and 19 DNA samples from SpA. None of the samples tested was positive for XMRV or MLV-like env sequences, indicating that XMRV is not involved in these pathologies.

AbbreviationsENVenvelope glycoprotein

GAPDHGlyceraldehyde 3-phosphate dehydrogenase

PCRPolymerase Chain Reaction

PTLVPrimate T-cell lymphotropic virus

SUEnv extracellular surface component.

Electronic supplementary materialThe online version of this article doi:10.1186-1742-4690-7-63 contains supplementary material, which is available to authorized users.

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Autor: Eric Jeziorski - Vincent Foulongne - Catherine Ludwig - Djamel Louhaem - Gilles Chiocchia - Michel Segondy - Michel Rodièr

Fuente: https://link.springer.com/







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