Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules sICAM-1 and sVCAM-1 and hemolysis markers among steady-state sickle cell anemia patientsReportar como inadecuado




Arginase levels and their association with Th17-related cytokines, soluble adhesion molecules sICAM-1 and sVCAM-1 and hemolysis markers among steady-state sickle cell anemia patients - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Annals of Hematology

, Volume 89, Issue 9, pp 877–882

First Online: 20 April 2010Received: 13 January 2010Accepted: 23 March 2010

Abstract

Sickle cell anemia SCA is characterized by a marked endothelial dysfunction, owing to many factors. Arginine metabolism can be related to the inflammatory chronic state presented by patients, playing a key role in their clinical outcome and vascular endothelium. We investigated the serum arginase levels in 50 SCA patients 22 men and 28 women, mean age of 17 ± 10.5 years and 28 healthy controls. Serum arginase levels were associated with biochemical hemolysis markers and cytokines involved in Th17 response, as well as levels of soluble intercellular adhesion molecule-1 sICAM-1 and vascular cell adhesion molecule-1 sVCAM-1. Arginase concentrations were higher in SCA patients, compared with controls p = 0.005, and were significantly and positively associated with total bilirubin p = 0.004, indirect bilirubin p = 0.04, and aspartate aminotransferase AST; p = 0.039 in the SCA patient group. Moreover, arginase was significantly and positively associated with transforming growth factor-beta TGF-beta; p = 0.008 among SCA patients. sICAM-1 was significantly and positively associated to reticulocytes p = 0.014 and AST p = 0.04. sVCAM-1 was likewise associated with lactate dehydrogenase p = 0.03. These data suggest a new insight into arginase metabolism, as we show here a shift in arginine catabolism, where TGF-beta may induces the arginase pathway instead of the nitric oxide pathway and a possible involvement of the vascular activation and the serum arginase in chronic hemolysis among SCA patients. Additional studies should be carried out in order to investigate the mechanisms by which TGF-beta participates in the metabolism of arginase in SCA patients.

KeywordsSickle cell anemia Arginine Arginase Th17 cells Soluble adhesion molecules TGF-β WVB and BAVC contributed equally to this manuscript.

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Autor: Wendell Vilas-Boas - Bruno A. V. Cerqueira - Angela M. D. Zanette - Mitermayer G. Reis - Manoel Barral-Netto - Marilda 

Fuente: https://link.springer.com/







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