Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care populationReportar como inadecuado

Adverse anthropometric risk profile in biochemically controlled acromegalic patients: comparison with an age- and gender-matched primary care population - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.


, Volume 13, Issue 3, pp 207–214

First Online: 04 February 2010


GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular risk profile in patients with controlled acromegaly and controls. A cross-sectional study. We evaluated anthropometric parameters height, weight, body mass index BMI, waist and hip circumference, waist to height ratio and, additionally, cardiovascular risk biomarkers fasting plasma glucose, HbA1c, triglycerides, total cholesterol, HDL, LDL, and lipoprotein a, in 81 acromegalic patients 58% cured compared to 320 age- and gender-matched controls ratio 1:4, sampled from the primary care patient cohort DETECT. The whole group of 81 acromegalic patients presented with significantly higher anthropometric parameters, such as weight, BMI, waist and hip circumference, but with more favourable cardiovascular risk biomarkers, such as fasting plasma glucose, total cholesterol, triglycerides and HDL levels, in comparison to their respective controls. Biochemically controlled acromegalic patients again showed significantly higher measurements of obesity, mainly visceral adiposity, than age- and gender-matched control patients BMI 29.5 ± 5.9 vs. 27.3 ± 5.8 kg-m; P = 0.020; waist circumference 100.9 ± 16.8 vs. 94.8 ± 15.5 cm; P = 0.031; hip circumference 110.7 ± 9.9 vs. 105.0 ± 11.7 cm; P = 0.001. No differences in the classical cardiovascular biomarkers were detected except for fasting plasma glucose and triglycerides. This effect could not be attributed to a higher prevalence of type 2 diabetes mellitus in the acromegalic patient group, since stratified analyses between the subgroup of patients with acromegaly and controls, both with type 2 diabetes mellitus, revealed that there were no significant differences in the anthropometric measurements. Biochemically cured acromegalic patients pertain an adverse anthropometric risk profile, mainly because of elevated adiposity measurements, such as BMI, waist and hip circumference, compared to an age- and gender-matched primary care population.

KeywordsAcromegaly GH IGF-1 Anthropometric parameters Cardiovascular risk biomarkers C. Dimopoulou and C. Sievers both authors contributed equally.

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Autor: C. Dimopoulou - C. Sievers - H. U. Wittchen - L. Pieper - J. Klotsche - J. Roemmler - J. Schopohl - H. J. Schneider - G.


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