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Journal of Experimental and Clinical Cancer Research

, 29:129

First Online: 17 September 2010Received: 28 July 2010Accepted: 17 September 2010

Abstract

BackgroundHuman 8-oguanine glycosylase 1hOGG1, voltage-dependent anion channel 1VDAC1, hexokinase 2HK-2, represented the process of oxidative DNA damage, cell apoptosis and glycolysis, respectively. This study aims to explore the association between expression of hOGG1, VDAC1, HK-2 and cervical carcinoma.

MethodsA case-control study was conducted. 65 cervical biopsy samples consist of 20 control and 45 cases. The expression of hOGG1, VDAC1 and HK-2 were examined with immunohistochemistryIHC, immunolabeling was evaluated with stereological cell counts.

ResultsThe data showed that the positive proportion of hOGG1 and HK-2 in the case group was higher than that of the control group P < 0.05. Further, there was an increasing trend for the positive proportion and expression degree of hOGG1 and HK-2 from Control, Mild cervical carcinoma MCC, Intermediate cervical carcinomaICC to Severe cervical carcinomaSCC in order P < 0.05. To VDAC1, the significant result was not obtained.

ConclusionsThe results suggested that there was a close association between expression of hOGG1, HK-2 and cervical cancer. hOGG1 and HK-2 might play a key role at the early stage of cervical cancer, and the findings of hOGG1 and HK-2 should be considered as a significant biomarker at the early stage of cervical cancer.

AbbreviationsCINcervical intraepithelial neoplasia

hOGG1human 8-oguanine glycosylase 1

VDAC1voltage-dependent anion channel 1

HK-2hexokinase 2

MCCmild cervical carcinoma including CINIand CINII

ICCintermediate cervical carcinoma implicating CINIII

SCCSevere cervical carcinoma implicating invasive squamous carcinoma.

Electronic supplementary materialThe online version of this article doi:10.1186-1756-9966-29-129 contains supplementary material, which is available to authorized users.

An erratum to this article is available at http:-dx.doi.org-10.1186-1756-9966-30-53.

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Autor: Peng Guo-Qing - Yang Yuan - Zhong Cai-Gao - Yin Hongling - Hu Gonghua - Tian Yan

Fuente: https://link.springer.com/







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