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Pediatric Nephrology

, Volume 25, Issue 11, pp 2311–2319

First Online: 30 July 2010Received: 08 April 2010Revised: 17 June 2010Accepted: 22 June 2010

Abstract

Calcium Ca-containing phosphate binders have been recommended for the treatment of hyperphosphatemia in children with chronic kidney disease. To study the effects of high Ca levels on trabecular bone volume BV and osteoprotegerin OPG expression in uremic young rats, a model of marked overcorrection of secondary hyperparathyroidism was created by providing a diet of high Ca to 5-6 nephrectomized young rats Nx-Ca for 4 weeks. The results of chondrocyte proliferation and apoptosis, osteoclastic activity, OPG expression and BV were compared among intact rats given the control diet, intact rats given a high Ca diet and 5-6 nephrectomized rats given the control diet Nx-Control and the high Ca diet Nx-Ca. Ionized Ca levels were higher and parathyroid hormone levels were lower in Nx-Ca rats than in the other groups. Final weight, final length and final tibial length of Nx-Ca rats were significantly less than those of the other groups, although the length gain did not differ among the groups. The hypertrophic zone width was markedly enlarged in Nx-Ca rats. Chondrocyte proliferation rates did not differ among the groups, whereas osteoclastic activity was decreased in Nx-Ca rats compared with the Nx-Control animals. The OPG expression and BV were increased in Nx-Ca rats compared with the Nx-Control rats. Increased BV should improve bone strength, whereas disturbance of osteoclastogenesis interferes with bone remodeling. Bone quality has yet to be determined in high Ca-fed uremic young rats.

KeywordsOsteoclastogenesis Osteoprotegerin Chronic kidney disease  Download fulltext PDF



Autor: Pornpimol Rianthavorn - Robert B. Ettenger - Isidro B. Salusky - Beatriz D. Kuizon

Fuente: https://link.springer.com/







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